The unifying focus of our laboratory's research program is to discover and apply small-molecule tools toward the study of pathogenic transcription in human cancers. We value chemical tools for two reasons. First, the fast action of small molecules – compared to genetic perturbations – allows for detailed study of target protein mechanism of action divorced from confounding secondary effects. Second, the close proximity of chemical tools to starting points in therapeutic science places our efforts in direct relevance to the discovery and development and of new cancer medicines. Therefore, we are pursuing chemical biological approaches within cancer model systems to study the interface of chromatin and cancer biology.