2022

​

Bishop TR, Subramanian C, Bilotta EM, Garnar-Wortzel L, Ramos AR, Zhang Y, Asiaban JN, Ott CJ, Rock CO, Erb MA. Metabolic adaptations underpin resistance to histone acetyltransferase inhibition. bioRxiv 2022. https://www.biorxiv.org/content/10.1101/2022.08.12.503669v1

​

Yuxiang Zhang, David Remillard, Ugoma Onubogu, Barbara Karakyriakou, Joshua N Asiaban, Anissa R Ramos, Kirsten Bowland, Timothy R Bishop, Christopher J Ott, Michalina Janiszewska, Benjamin F Cravatt, Michael A Erb. Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities. bioRxiv 2022. https://www.biorxiv.org/content/10.1101/2022.05.30.493851v1.full

​

2021

​

Zhang Y, Erb MA. Enabling cancer target validation with genetically encoded systems for ligand-induced protein degradation. Curr Res Chem Biology (2021). https://doi.org/10.1016/j.crchbi.2021.100011

​

Garnar-Wortzel L,* Bishop TR,* Kitamura S,* Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA. Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia. ACS Cent Sci (2021). https://doi.org/10.1021/acscentsci.0c01550

​

Koh M, Ahmad I, Ko Y, Zhang Y, Martinez TF, Diedrich JK, Chu Q, Moresco JJ, Erb MA, Saghatelian A†, Schultz PG†, Bollong MJ†. A short ORF-encoded transcriptional regulator. Proc National Acad Sci 118, e2021943118. (2021) †Co-corresponding

​

2020

​

Asiaban, JN; Milosevich, N; Chen, E; Bishop, TR; Wang, J; Zhang, Y; Ackerman, CJ; Hampton, EN; Young, TS; Hull, MV; Cravatt, BF.; Erb, MA. Cell-Based Ligand Discovery for the ENL YEATS Domain. ACS Chem Biol 2020, 15 (4), 895–903. https://doi.org/10.1021/acschembio.0c00124.

​

Erb, MA. Processing for Destruction. Nat Chem Biol 2020, 16 (1), 3–4. https://doi.org/10.1038/s41589-019-0428-x.

​

2019

​

Bishop, TR; Zhang, Y; Erb, MA. Pharmacological Modulation of Transcriptional Coregulators in Cancer. Trends Pharmacol Sci 2019, 40 (6), 388–402. https://doi.org/10.1016/j.tips.2019.04.004.

​

_____________________________________________________________________________________

​

Graduate publications

 

2018

​

Nabet, B; Roberts, JM; Buckley, DL; Paulk, J; Dastjerdi, S; Yang, A; Leggett, AL; Erb, MA; Lawlor, MA; Souza, A; Scott, TG; Vittori, S; Perry, JA; Qi, J; Winter, GE; Wong, K-K.; Gray, NS; Bradner, JE. The dTAG System for Immediate and Target-Specific Protein Degradation. Nat Chem Biol 2018, 14 (5), 431–441. https://doi.org/10.1038/s41589-018-0021-8.

​

Gechijian, LN; Buckley, DL; Lawlor, MA; Reyes, JM; Paulk, J; Ott, CJ; Winter, GE; Erb, MA; Scott, TG; Xu, M; Seo, H-S.; Dhe-Paganon, S; Kwiatkowski, NP; Perry, JA; Qi, J; Gray, NS; Bradner, J. E. Functional TRIM24 Degrader via Conjugation of Ineffectual Bromodomain and VHL Ligands. Nat Chem Biol 2018, 14 (4), 405–412. https://doi.org/10.1038/s41589-018-0010-y.

​

Zeid, R; Lawlor, MA; Poon, E; Reyes, JM; Fulciniti, M; Lopez, MA; Scott, TG; Nabet, B; Erb, MA; Winter, GE; Jacobson, Z; Polaski, DR; Karlin, KL; Hirsch, RA; Munshi, NP; Westbrook, TF; Chesler, L; Lin, CY; Bradner, JE. Enhancer Invasion Shapes MYCN-Dependent Transcriptional Amplification in Neuroblastoma. Nat Genet 2018, 463 (4), 899. https://doi.org/10.1038/s41588-018-0044-9.

​

Ishoey, M; Chorn, S; Singh, N; Jaeger, MG; Brand, M; Paulk, J; Bauer, S; Erb, MA; Parapatics, K; Müller, AC; Bennett, KL; Ecker, GF; Bradner, JE; Winter, GE. Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders. Acs Chem Biol 2018, 13 (3), 553–560. https://doi.org/10.1021/acschembio.7b00969.

​

Olson, CM; Jiang, B; Erb, MA; Liang, Y; Doctor, ZM; Zhang, Z; Zhang, T; Kwiatkowski, N; Boukhali, M; Green, JL; Haas, W; Nomanbhoy, T; Fischer, ES; Young, RA; Bradner, JE; Winter, GE; Gray, NS. Pharmacological Perturbation of CDK9 Using Selective CDK9 Inhibition or Degradation. Nat Chem Biol 2018, 14 (2), 163–170. https://doi.org/10.1038/nchembio.2538.

​

2017

​

Winter, GE*; Mayer, A*; Buckley, DL*; Erb, MA*; Roderick, JE; Vittori, S; Reyes, JM; Iulio, J di; Souza, A; Ott, CJ; Roberts, JM; Zeid, R; Scott, TG; Paulk, J; Lachance, K; Olson, CM; Dastjerdi, S; Bauer, S; Lin, CY; Gray, NS; Kelliher, MA; Churchman, LS; Bradner, JE. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell 2017, 67 (1), 5-18.e19. https://doi.org/10.1016/j.molcel.2017.06.004.

​

Erb, MA; Scott, TG.; Li, BE; Xie, H; Paulk, J; Seo, H-S; Souza, A; Roberts, JM; Dastjerdi, S; Buckley, DL; Sanjana, NE; Shalem, O; Nabet, B; Zeid, R; Offei-Addo, NK; Dhe-Paganon, S; Zhang, F; Orkin, SH; Winter, GE; Bradner, JE. Transcription Control by the ENL YEATS Domain in Acute Leukaemia. Nature 2017, 543(7644), 270–274. https://doi.org/10.1038/nature21688.

​

Wan, L; Wen, H; Li, Y; Lyu, J; Xi, Y; Hoshii, T; Joseph, JK; Wang, X; Loh, Y-HE; Erb, MA; Souza, AL; Bradner, JE; Shen, L; Li, W; Li, H; Allis, CD; Armstrong, SA; Shi, X. ENL Links Histone Acetylation to Oncogenic Gene Expression in Acute Myeloid Leukaemia. Nature 2017, 543 (7644), 265–269. https://doi.org/10.1038/nature21687.