Publications
2020

Asiaban, JN; Milosevich, N; Chen, E; Bishop, TR; Wang, J; Zhang, Y; Ackerman, CJ; Hampton, EN; Young, TS; Hull, MV; Cravatt, BF.; Erb, MA. Cell-Based Ligand Discovery for the ENL YEATS Domain. ACS Chem Biol 2020, 15 (4), 895–903. https://doi.org/10.1021/acschembio.0c00124.

Erb, MA. Processing for Destruction. Nat Chem Biol 2020, 16 (1), 3–4. https://doi.org/10.1038/s41589-019-0428-x.

2019

Bishop, TR; Zhang, Y; Erb, MA. Pharmacological Modulation of Transcriptional Coregulators in Cancer. Trends Pharmacol Sci 2019, 40 (6), 388–402. https://doi.org/10.1016/j.tips.2019.04.004.

2018

Nabet, B; Roberts, JM; Buckley, DL; Paulk, J; Dastjerdi, S; Yang, A; Leggett, AL; Erb, MA; Lawlor, MA; Souza, A; Scott, TG; Vittori, S; Perry, JA; Qi, J; Winter, GE; Wong, K-K.; Gray, NS; Bradner, JE. The dTAG System for Immediate and Target-Specific Protein Degradation. Nat Chem Biol 2018, 14 (5), 431–441. https://doi.org/10.1038/s41589-018-0021-8.

Gechijian, LN; Buckley, DL; Lawlor, MA; Reyes, JM; Paulk, J; Ott, CJ; Winter, GE; Erb, MA; Scott, TG; Xu, M; Seo, H-S.; Dhe-Paganon, S; Kwiatkowski, NP; Perry, JA; Qi, J; Gray, NS; Bradner, J. E. Functional TRIM24 Degrader via Conjugation of Ineffectual Bromodomain and VHL Ligands. Nat Chem Biol 2018, 14 (4), 405–412. https://doi.org/10.1038/s41589-018-0010-y.

Zeid, R; Lawlor, MA; Poon, E; Reyes, JM; Fulciniti, M; Lopez, MA; Scott, TG; Nabet, B; Erb, MA; Winter, GE; Jacobson, Z; Polaski, DR; Karlin, KL; Hirsch, RA; Munshi, NP; Westbrook, TF; Chesler, L; Lin, CY; Bradner, JE. Enhancer Invasion Shapes MYCN-Dependent Transcriptional Amplification in Neuroblastoma. Nat Genet 2018, 463 (4), 899. https://doi.org/10.1038/s41588-018-0044-9.

Ishoey, M; Chorn, S; Singh, N; Jaeger, MG; Brand, M; Paulk, J; Bauer, S; Erb, MA; Parapatics, K; Müller, AC; Bennett, KL; Ecker, GF; Bradner, JE; Winter, GE. Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders. Acs Chem Biol 2018, 13 (3), 553–560. https://doi.org/10.1021/acschembio.7b00969.

Olson, CM; Jiang, B; Erb, MA; Liang, Y; Doctor, ZM; Zhang, Z; Zhang, T; Kwiatkowski, N; Boukhali, M; Green, JL; Haas, W; Nomanbhoy, T; Fischer, ES; Young, RA; Bradner, JE; Winter, GE; Gray, NS. Pharmacological Perturbation of CDK9 Using Selective CDK9 Inhibition or Degradation. Nat Chem Biol 2018, 14 (2), 163–170. https://doi.org/10.1038/nchembio.2538.

2017

Winter, GE*; Mayer, A*; Buckley, DL*; Erb, MA*; Roderick, JE; Vittori, S; Reyes, JM; Iulio, J di; Souza, A; Ott, CJ; Roberts, JM; Zeid, R; Scott, TG; Paulk, J; Lachance, K; Olson, CM; Dastjerdi, S; Bauer, S; Lin, CY; Gray, NS; Kelliher, MA; Churchman, LS; Bradner, JE. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell 2017, 67 (1), 5-18.e19. https://doi.org/10.1016/j.molcel.2017.06.004.

Erb, MA; Scott, TG.; Li, BE; Xie, H; Paulk, J; Seo, H-S; Souza, A; Roberts, JM; Dastjerdi, S; Buckley, DL; Sanjana, NE; Shalem, O; Nabet, B; Zeid, R; Offei-Addo, NK; Dhe-Paganon, S; Zhang, F; Orkin, SH; Winter, GE; Bradner, JE. Transcription Control by the ENL YEATS Domain in Acute Leukaemia. Nature 2017, 543(7644), 270–274. https://doi.org/10.1038/nature21688.

Wan, L; Wen, H; Li, Y; Lyu, J; Xi, Y; Hoshii, T; Joseph, JK; Wang, X; Loh, Y-HE; Erb, MA; Souza, AL; Bradner, JE; Shen, L; Li, W; Li, H; Allis, CD; Armstrong, SA; Shi, X. ENL Links Histone Acetylation to Oncogenic Gene Expression in Acute Myeloid Leukaemia. Nature 2017, 543 (7644), 265–269. https://doi.org/10.1038/nature21687.

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© 2018 by The Erb Laboratory.