Featured Publications
Full list of publications
2023
Bishop TR, Subramanian C, Bilotta EM, Garnar-Wortzel L, Ramos AR, Zhang Y, Asiaban JN, Ott CJ, Rock CO, Erb MA. Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition. Nat Chem Biol. (2023). https://www.nature.com/articles/s41589-023-01320-7
As featured in Nature Chemical Biology "News and Views"
Nathaniel W. Snyder & Jordan L. Meier. Metabolic regulation of epigenetic drug resistance. Nat Chem Biol. (2023).
https://www.nature.com/articles/s41589-023-01323-4
Yuxiang Zhang, David Remillard, Ugoma Onubogu, Barbara Karakyriakou, Joshua N Asiaban, Anissa R Ramos, Kirsten Bowland, Timothy R Bishop, Paige A Barta, Stephanie Nance, Adama D Durbin, Christopher J Ott, Michalina Janiszewska, Benjamin F Cravatt, Michael A Erb. Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities. Nat Struct Mol Biol. (2023). https://www.nature.com/articles/s41594-023-01041-4
2021
Zhang Y, Erb MA. Enabling cancer target validation with genetically encoded systems for ligand-induced protein degradation. Curr Res Chem Biology (2021). https://doi.org/10.1016/j.crchbi.2021.100011
Garnar-Wortzel L,* Bishop TR,* Kitamura S,* Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA. Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia. ACS Cent Sci (2021). https://doi.org/10.1021/acscentsci.0c01550
Koh M, Ahmad I, Ko Y, Zhang Y, Martinez TF, Diedrich JK, Chu Q, Moresco JJ, Erb MA, Saghatelian A†, Schultz PG†, Bollong MJ†. A short ORF-encoded transcriptional regulator. Proc National Acad Sci 118, e2021943118. (2021) †Co-corresponding
2020
Asiaban, JN; Milosevich, N; Chen, E; Bishop, TR; Wang, J; Zhang, Y; Ackerman, CJ; Hampton, EN; Young, TS; Hull, MV; Cravatt, BF.; Erb, MA. Cell-Based Ligand Discovery for the ENL YEATS Domain. ACS Chem Biol 2020, 15 (4), 895–903. https://doi.org/10.1021/acschembio.0c00124.
Erb, MA. Processing for Destruction. Nat Chem Biol 2020, 16 (1), 3–4. https://doi.org/10.1038/s41589-019-0428-x. News and Views
2019
Bishop, TR; Zhang, Y; Erb, MA. Pharmacological Modulation of Transcriptional Coregulators in Cancer. Trends Pharmacol Sci 2019, 40 (6), 388–402. https://doi.org/10.1016/j.tips.2019.04.004.
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Graduate publications
2018
Nabet, B; Roberts, JM; Buckley, DL; Paulk, J; Dastjerdi, S; Yang, A; Leggett, AL; Erb, MA; Lawlor, MA; Souza, A; Scott, TG; Vittori, S; Perry, JA; Qi, J; Winter, GE; Wong, K-K.; Gray, NS; Bradner, JE. The dTAG System for Immediate and Target-Specific Protein Degradation. Nat Chem Biol 2018, 14 (5), 431–441. https://doi.org/10.1038/s41589-018-0021-8.
Gechijian, LN; Buckley, DL; Lawlor, MA; Reyes, JM; Paulk, J; Ott, CJ; Winter, GE; Erb, MA; Scott, TG; Xu, M; Seo, H-S.; Dhe-Paganon, S; Kwiatkowski, NP; Perry, JA; Qi, J; Gray, NS; Bradner, J. E. Functional TRIM24 Degrader via Conjugation of Ineffectual Bromodomain and VHL Ligands. Nat Chem Biol 2018, 14 (4), 405–412. https://doi.org/10.1038/s41589-018-0010-y.
Zeid, R; Lawlor, MA; Poon, E; Reyes, JM; Fulciniti, M; Lopez, MA; Scott, TG; Nabet, B; Erb, MA; Winter, GE; Jacobson, Z; Polaski, DR; Karlin, KL; Hirsch, RA; Munshi, NP; Westbrook, TF; Chesler, L; Lin, CY; Bradner, JE. Enhancer Invasion Shapes MYCN-Dependent Transcriptional Amplification in Neuroblastoma. Nat Genet 2018, 463 (4), 899. https://doi.org/10.1038/s41588-018-0044-9.
Ishoey, M; Chorn, S; Singh, N; Jaeger, MG; Brand, M; Paulk, J; Bauer, S; Erb, MA; Parapatics, K; Müller, AC; Bennett, KL; Ecker, GF; Bradner, JE; Winter, GE. Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders. Acs Chem Biol 2018, 13 (3), 553–560. https://doi.org/10.1021/acschembio.7b00969.
Olson, CM; Jiang, B; Erb, MA; Liang, Y; Doctor, ZM; Zhang, Z; Zhang, T; Kwiatkowski, N; Boukhali, M; Green, JL; Haas, W; Nomanbhoy, T; Fischer, ES; Young, RA; Bradner, JE; Winter, GE; Gray, NS. Pharmacological Perturbation of CDK9 Using Selective CDK9 Inhibition or Degradation. Nat Chem Biol 2018, 14 (2), 163–170. https://doi.org/10.1038/nchembio.2538.
2017
Winter, GE*; Mayer, A*; Buckley, DL*; Erb, MA*; Roderick, JE; Vittori, S; Reyes, JM; Iulio, J di; Souza, A; Ott, CJ; Roberts, JM; Zeid, R; Scott, TG; Paulk, J; Lachance, K; Olson, CM; Dastjerdi, S; Bauer, S; Lin, CY; Gray, NS; Kelliher, MA; Churchman, LS; Bradner, JE. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell 2017, 67 (1), 5-18.e19. https://doi.org/10.1016/j.molcel.2017.06.004.
Erb, MA; Scott, TG.; Li, BE; Xie, H; Paulk, J; Seo, H-S; Souza, A; Roberts, JM; Dastjerdi, S; Buckley, DL; Sanjana, NE; Shalem, O; Nabet, B; Zeid, R; Offei-Addo, NK; Dhe-Paganon, S; Zhang, F; Orkin, SH; Winter, GE; Bradner, JE. Transcription Control by the ENL YEATS Domain in Acute Leukaemia. Nature 2017, 543(7644), 270–274. https://doi.org/10.1038/nature21688.
Wan, L; Wen, H; Li, Y; Lyu, J; Xi, Y; Hoshii, T; Joseph, JK; Wang, X; Loh, Y-HE; Erb, MA; Souza, AL; Bradner, JE; Shen, L; Li, W; Li, H; Allis, CD; Armstrong, SA; Shi, X. ENL Links Histone Acetylation to Oncogenic Gene Expression in Acute Myeloid Leukaemia. Nature 2017, 543 (7644), 265–269. https://doi.org/10.1038/nature21687.